A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies
نویسندگان
چکیده
منابع مشابه
LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration, and anchorage. W...
متن کاملKASH and SUN proteins
KASH and SUN proteins Quick guides at-bat, including which fielders were involved, and so on. At that point, I was amused to see that my friend Kyle was also keeping score, but that he marked every at-bat with a simple and uninformative ‘X’ when each batter was retired; consequently, his whole data sheet on the opposing team was just one string of Xs after another. Although I was feeling the su...
متن کاملA new SUN role – no KASH required?
In eukaryotic cells, a close physical association between the microtubule-organising centre (MTOC) and the nucleus is essential, and its disruption leads to severe cellular abnormalities. MTOC–nucleus attachment is maintained by SUN and KASH proteins, which are found in the inner and outer nuclear membranes, respectively, and typically interact to form nuclear-envelope-spanning LINC complexes. ...
متن کاملJcb_201409047 1..12
Correspondence to Gregg G. Gundersen: [email protected] Abbreviations used in this paper: ABD, actin-binding domain; CH, calponin homology; KASH, Klarsicht, ANC-1, and Syne homology; LINC, linker of nucleoskeleton and cytoskeleton; SR, spectrin repeat; SUN, Sad1 and UNC-84; TAN, transmembrane actin–associated nuclear. Introduction The linker of nucleoskeleton and cytoskeleton (LINC) complex is ...
متن کاملThe Molecular Basis of LINC Complex Formation
The nucleus is the hallmark of the eukaryotic cell. It contains most of the genetic material and it separates the processes of replication and transcription from that of translation. Communication between the nucleus and the cytoplasm occurs mostly through openings in the nuclear envelope composed of nuclear pore complexes. These massive assemblies allow for regulated transport of macromolecule...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.60175